Research Highlights

Our research focus is on circuit neuroscience, developing a bottom-up understanding of how neural networks in the brain operate. Essential to this quest is the application of advance approaches in mathematical modeling and computer simulation to experimental data. To this end, the Kavli Institute for Brain Science fosters collaborations between theorists and experimentalists working together to study how neural circuits control mental function and behavior. Highlighting this special relationship between theorist and experimentalist, the members of the Kavli Institute are also part of the Center for Theoretical Neuroscience at Columbia, which celebrated its 20th anniversary in 2025.

 

Featured Publications

Prediction of neural activity in connectome-constrained recurrent networks. Beiran M, Litwin-Kumar A. Nat Neurosci. 2025 Oct 27

Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model. Chau HY, Miller KD, Palmigiano A. Proc Natl Acad Sci U S A. 2025 Aug 5

Stabilized Supralinear Network Model of Responses to Surround Stimuli in Primary Visual Cortex Obeid D, Miller KD. eNeuro. 2025 May 20

Dynamics of striatal action selection and reinforcement learning. Lindsey JW, Markowitz J, Gillis WF, Datta SR, Litwin-Kumar A. Elife. 2025 May 8

DREDge: robust motion correction for high-density extracellular recordings across species. Windolf C, Yu H, Paulk AC, Meszéna D, Muñoz W, Boussard J, Hardstone R, Caprara I, Jamali M, Kfir Y, Xu D, Chung JE, Sellers KK, Ye Z, Shaker J, Lebedeva A, Raghavan RT, Trautmann E, Melin M, Couto J, Garcia S, Coughlin B, Elmaleh M, Christianson D, Greenlee JDW, Horváth C, Fiáth R, Ulbert I, Long MA, Movshon JA, Shadlen MN, Churchland MM, Churchland AK, Steinmetz NA, Chang EF, Schweitzer JS, Williams ZM, Cash SS, Paninski L, Varol E. Nat Methods. 2025 Apr

Contextual modulation emerges by integrating feedforward and feedback processing in mouse visual cortex. Di Santo S, Dipoppa M, Keller A, Roth M, Scanziani M, Miller KD. Cell Rep. 2025 Jan 28

Understanding the neural code of stress to control anhedonia. Xia F, Fascianelli V, Vishwakarma N, Ghinger FG, Kwon A, Gergues MM, Lalani LK, Fusi S, Kheirbek MA. Nature. 2025 Jan