Kavli Institute NeuroLunch
March 15th, 2016
David Doobin, MD/PhD Student, Vallee Lab
"Severe NDE1-Mediated Microcephaly Results from Neural Progenitor Cell Cycle Arrest at Multiple Specific Stages"
I am currently a 5th-year MD/PhD student in the laboratory of Richard Vallee. I am interested in better understanding developmental neurobiology, with the hope that furthering our knowledge of such processes will allow us to better understand developmental and neuro-oncological diseases.
By examining the role for the dynein-adaptor protein NDE1 in the proliferation of radial glia stem cells we have uncovered three distinct non-mitotic roles during the cell cycle. Alterations in NDE1 function, such as those seen in patients with human NDE1 mutations, severely compromises the ability of these stem cells to proliferate, and likely contributes to the severe and devastating form of microcephaly seen in these patients.
Seminars are held in:
Rm. 900 Sherman Fairchild Bldg. - Note the new room location
12:00 pm - 1:00pm
1212 Amsterdam Ave.
New York, NY 10027